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Rabbit
Anti-ABCG2/Gold
Cat. Number:
bs-4780R-Gold
Quantity size:
100ul
15nm
Concentration:
0.4mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Also known as:
ABC transporter;
ABC15;
ABCG 2;
ABCG2;
ABCG2_HUMAN;
ABCP;
ATP binding cassette sub family G (WHITE) member 2;
ATP binding cassette transporter G2;
ATP-binding cassette sub-family G member 2;
BCRP;
BCRP1;
BMDP;
Breast cancer resistance protein;
CD338;
CDw338;
CDw338 antigen;
EST157481;
GOUT1;
MGC102821;
Mitoxantrone resistance associated protein;
Mitoxantrone resistance-associated protein;
MRX;
Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2;
MXR;
MXR1;
Placenta specific ATP binding cassette transporter;
Placenta specific MDR protein;
Placenta-specific ATP-binding cassette transporter;
UAQTL1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with:
(predicted: )
●
Immunogen: KLH conjugated synthetic peptide derived from human ABCG2/CD338.
●
Predicted Molecular Weight: 72kDa.
Storage:
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
Application:
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.