| 產(chǎn)品編號 | bs-5713R-PE-Cy5.5 |
| 英文名稱(chēng) | Rabbit Anti-HOXA5/PE-Cy5.5 Conjugated antibody |
| 中文名稱(chēng) | PE-Cy5.5標記的同源異型盒基因HOXA5蛋白抗體 |
| 別 名 | Homeo box 1C antibody Homeobox A5 antibody Homeobox protein HOXA5 antibody HOX 1 antibody HOX 1.3 antibody HOX 1C antibody HOX1 antibody HOX1.3 antibody HOX1C antibody; HXA5_HUMAN. |
| 規格價(jià)格 | 100ul/2980元 購買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 染色質(zhì)和核信號 細胞周期蛋白 轉錄調節因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29 kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HOXA5 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. Subcellular Location: Nucleus. Similarity: Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 3202 Human Entrez Gene: 15402 Mouse Omim: 142952 Human SwissProt: P20719 Human SwissProt: P09021 Mouse Unigene: 655218 Human Unigene: 173 Mouse Unigene: 8465 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. p53基因保護細胞不會(huì )癌變，HOXA5協(xié)助細胞的p53保持適當水平。如果HOXA5水平下降或完全缺乏，p53基因就不能防止細胞癌變。低水平的HOXA5通過(guò)另一種促甲基化機制使基因不能表達而發(fā)生。正常狀態(tài)下，p53腫瘤抑制蛋白發(fā)現DNA的損傷，將信息傳遞給細胞以修復損傷或者導致死亡。過(guò)少或沒(méi)有p53不僅減弱細胞正常功能，而且降低細胞感受損傷的能力。因此，若細胞缺少HOXA5蛋白也很可能是腫瘤發(fā)展的重要過(guò)程。 |
