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    Rabbit Anti-Phospho-Tyk2(Tyr1054 + Tyr1055)/HRP Conjugated antibody (bs-3437R-HRP)
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@bioss.com.cn
    說(shuō) 明 書(shū): 100ul  
    100ul/2980.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-3437R-HRP
    英文名稱(chēng) Rabbit Anti-Phospho-Tyk2(Tyr1054 + Tyr1055)/HRP Conjugated antibody
    中文名稱(chēng) 辣根過(guò)氧化物酶標記的磷酸化非受體酪氨酸蛋白激酶2抗體
    別    名 TYK2 (phospho Y1054 + Y1055); TYK2(Phospho-Tyr1054/1055); Tyk2(phospho Y1054/1055); TYK2 (phospho Tyr1054/1055); p-TYK2 (Tyr1054/1055); JTK 1; JTK1; TYK 2; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Protein Tyrosine Kinase 2; Tyrosine kinase 2; TYK2_HUMAN; Non-receptor tyrosine-protein kinase TYK2.  
    規格價(jià)格 100ul/2980元 購買(mǎi)        大包裝/詢(xún)價(jià)
    說(shuō) 明 書(shū) 100ul  
    產(chǎn)品類(lèi)型 磷酸化抗體 
    研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    交叉反應 Human, Mouse, Rat,  (predicted: Dog, )
    產(chǎn)品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 134kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Tyk2 around the phosphorylation site of Tyr1054/1055
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 background:
    This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].

    Function:
    Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

    Subunit:
    Interacts with JAKMIP1.

    Tissue Specificity:
    Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

    DISEASE:
    Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

    Similarity:
    Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
    Contains 1 FERM domain.
    Contains 2 protein kinase domains.
    Contains 1 SH2 domain.

    Database links:

    Entrez Gene: 7297 Human

    Entrez Gene: 54721 Mouse

    Entrez Gene: 100361294 Rat

    Omim: 176941 Human

    SwissProt: P29597 Human

    SwissProt: Q9R117 Mouse

    Unigene: 75516 Human

    Unigene: 20249 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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