• <tt id="uu8uu"><rt id="uu8uu"></rt></tt>
    <li id="uu8uu"><table id="uu8uu"></table></li>
  • 掃碼關(guān)注公眾號           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
      
    客服熱線(xiàn):400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
    產(chǎn)品中心-北京博奧森生物技術(shù)有限公司
    首頁(yè) > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
    Rabbit Anti-Phospho-Torc1 (Ser151)/BF647 Conjugated antibody (bs-3453R-BF647)
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@bioss.com.cn
    說(shuō) 明 書(shū): 100ul  
    100ul/2980.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-3453R-BF647
    英文名稱(chēng) Rabbit Anti-Phospho-Torc1 (Ser151)/BF647 Conjugated antibody
    中文名稱(chēng) BF647標記的磷酸化CREB轉錄共激
    別    名 Phospho-Torc1/Crtc1 (Ser151); Phospho-Torc1(Ser151); P-Torc1 (Ser151); Crtc1 (Ser151); Crtc1 (Phospho S151); CREB regulated transcription coactivator 1; CRTC1; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated protein 1; also known as MucoEpidermoid Carcinoma Translocated 1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1; CRTC1_HUMAN.  
    規格價(jià)格 100ul/2980元 購買(mǎi)        大包裝/詢(xún)價(jià)
    說(shuō) 明 書(shū) 100ul  
    產(chǎn)品類(lèi)型 磷酸化抗體 
    研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號轉導  轉錄調節因子  激酶和磷酸酶  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產(chǎn)品應用 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 70kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 background:
    which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

    Subunit:
    Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

    Subcellular Location:
    Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.

    Tissue Specificity:
    Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

    Post-translational modifications:
    Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR

    DISEASE:
    Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

    Similarity:
    Belongs to the TORC family.

    Database links:

    Entrez Gene: 23373?/span>Human

    Entrez Gene: 382056?/span>Mouse

    Entrez Gene: 684527?/span>Rat

    Omim: 607536?/span>Human

    SwissProt: Q6UUV9?/span>Human

    SwissProt: Q68ED7?/span>Mouse

    SwissProt: Q157S1?/span>Rat

    Unigene: 371096?/span>Human

    Unigene: 428214?/span>Human

    Unigene: 227767?/span>Mouse

    Unigene: 208248?/span>Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    版權所有 2004-2026 www.life-us.com 北京博奧森生物技術(shù)有限公司
    通過(guò)國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號: 00124Q34771R2M/1100
    通過(guò)國際醫療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號: CQC24QY10047R0M/1100
    京ICP備05066980號-1         京公網(wǎng)安備110107000727號
    国产日韩精品在线观看-久久国产精品亚洲AV三区色最新-亚洲国产日韩精品一区二区-日韩AⅤ激情无码