| 產(chǎn)品編號 | bsm-63299R |
| 英文名稱(chēng) | phospho-Tuberin (S939) Recombinant Rabbit mAb |
| 中文名稱(chēng) | 磷酸化馬鈴薯球蛋白(結節性硬化)重組兔單抗 |
| 別 名 | PPP1R160; tsc2; TSC4; Tuberin. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號 | 5D7 |
| 交叉反應 | Human,Mouse |
| 產(chǎn)品應用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 201 kDa |
| 檢測分子量 | 200 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Tuberin around the phosphorylation site of S939: RST-pS-LNER |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. SWISS: P49815 Gene ID: 7249 Tuberin 為180kD-220的蛋白產(chǎn)生于結節性硬化（TSC-2）位于染色體16的基因。結節性硬化為常染色體疾病已知為斑痣性錯構瘤病其特征為廣泛性發(fā)展呈良性生長(cháng)，在許多組織與器官中描述為錯構瘤。Tuberin被認為在GTPase活動(dòng)性蛋白中起作用調節細胞內吞與作為腫瘤抑制子。Tuberin低水平廣泛性表達在大多數組織中，而在皮層神經(jīng)元、小腦浦肯野氏細胞、脊索運動(dòng)神經(jīng)元、胰島B細胞、心肌、腎臟與皮膚的小血管中表達增加。 |
