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    PTPRN2 Rabbit pAb (bs-19591R)  
    訂購熱線(xiàn):400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
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    50ul/1180.00元
    100ul/1980.00元
    200ul/2800.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-19591R
    英文名稱(chēng) PTPRN2 Rabbit pAb
    中文名稱(chēng) 胰島細胞自身抗原相關(guān)蛋白PTPRN2抗體
    別    名 IA 2beta; IA2beta; IAR; IAR/receptor like protein tyrosine phosphatase; ICAAR; Islet cell autoantigen related protein; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase receptor pi; Protein tyrosine phosphatase, receptor type, N polypeptide 2; PTPR2_HUMAN; Ptprn2; PTPRP; R PTP N2; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; Tyrosine phosphatase IA 2 beta.  
    研究領(lǐng)域 細胞生物  信號轉導  激酶和磷酸酶  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 (predicted: Human)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 109 kDa
    檢測分子量
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human PTPRN2: 101-200/1015 <Extracellular>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

    Function:
    Implicated in development of nervous system and pancreatic endocrine cells.

    Subcellular Location:
    Membrane.

    Tissue Specificity:
    Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

    Post-translational modifications:
    Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

    Similarity:
    Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.

    SWISS:
    Q92932

    Gene ID:
    5799

    Database links:

    Entrez Gene: 5799 Human

    Entrez Gene: 19276 Mouse

    Entrez Gene: 29714 Rat

    Omim: 601698 Human

    SwissProt: Q92932 Human

    SwissProt: P80560 Mouse

    SwissProt: Q63475 Rat

    Unigene: 490789 Human

    Unigene: 206054 Mouse

    Unigene: 11044 Rat



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