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    SF1 Rabbit pAb (bs-17679R)  
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    50ul/1180.00元
    100ul/1980.00元
    200ul/2800.00元
    大包裝/詢(xún)價(jià)
    產(chǎn)品編號 bs-17679R
    英文名稱(chēng) SF1 Rabbit pAb
    中文名稱(chēng) 剪接因子1抗體
    別    名 SF01_HUMAN; Splicing factor 1; ZFM1; ZNF162; Mammalian branch point-binding protein(BBP; mBBP); Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162;  
    研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  轉錄調節因子  鋅指蛋白  表觀(guān)遺傳學(xué)  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,GuineaPig,Horse,Danio)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 68 kDa
    檢測分子量
    細胞定位 細胞核 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human splicing factor 1: 251-350/639 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

    Function:
    SF1 contains 1 KH domain, 1 CCHC type zinc finger, a nuclear transport domain and glutamine and proline rich regions. It is necessary for the ATP dependent first step of spliceosome assembly and binds to the intron branch point sequence (BPS) 5' UACUAAC 3' of the pre mRNA. It may act as transcription repressor. There are 6 named isoforms produced by alternative splicing.

    Subcellular Location:
    Nuclear

    Tissue Specificity:
    Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.

    Post-translational modifications:
    Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.

    Similarity:
    Belongs to the BBP/SF1 family.
    Contains 1 CCHC-type zinc finger.
    Contains 1 KH domain.

    SWISS:
    Q15637

    Gene ID:
    7536

    Database links:

    Entrez Gene: 7536 Human

    Entrez Gene: 22668 Mouse

    SwissProt: Q15637 Human

    SwissProt: Q64213 Mouse



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