| 產(chǎn)品編號 | bsm-2313M |
| 英文名稱(chēng) | CRIPTO Mouse mAb |
| 中文名稱(chēng) | 畸胎瘤衍化生長(cháng)因子單克隆抗體 |
| 別 名 | CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-like cripto protein CR1; TDGF 1; TDGF-1; TDGF1; Teratocarcinoma derived growth factor 1; Teratocarcinoma-derived growth factor 1; teratocarcinoma-derived growth factor 1 isoform 1 precursor; TDGF1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長(cháng)因子和激素 |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號 | 1F10 |
| 交叉反應 | (predicted: Human) |
| 產(chǎn)品應用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 13 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TDGF1: 21-100/188 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Subunit: Interacts with the activin type-1 receptor ACVR1B. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Similarity: Contains 1 EGF-like domain. SWISS: P13385 Gene ID: 6997 Database links: Entrez Gene: 6997 Human Entrez Gene: 21667 Mouse Omim: 187395 Human SwissProt: P13385 Human SwissProt: P51865 Mouse Unigene: 385870 Human Unigene: 5090 Mouse Cripto-1是表皮生長(cháng)因子-Cripto-FRL-Criptic(EGF-CFC)家族成員之一, 屬于轉化生長(cháng)細胞TGF-β蛋白家族及Nodal蛋白質(zhì)的共同受體。Cripto蛋白對于胚胎的發(fā)育占有非常重要的地位。 Cripto-1在人類(lèi)的多種腫瘤如結腸癌、乳腺癌、卵巢癌、胰腺癌等中高表達，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信號通路,介導細胞增殖和抑制細胞凋亡，Cripto蛋白的單細胞繁殖抗體，可以有效抑制一些癌細胞的生長(cháng)。 |
