| 產(chǎn)品編號 | bs-3358R |
| 英文名稱(chēng) | Phospho-HSL (Ser660) Rabbit pAb |
| 中文名稱(chēng) | 磷酸化荷爾蒙敏感脂肪酶抗體 |
| 別 名 | Hormone sensitive lipase; Hormone sensitive lipase testicular isoform; HSL; LHS; Lipase hormone sensitive; LIPE. |
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Specific References (1) | bs-3358R has been referenced in 1 publications.
[IF=4.486] Chengqian Li. et al. Mutation of the novel acetylation site at K414R of BECN1 is involved in adipocyte differentiation and lipolysis. 2021 Jun 04 WB ; Human.
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| 產(chǎn)品類(lèi)型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 心血管 免疫學(xué) 信號轉導 生長(cháng)因子和激素 轉錄調節因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Mouse,Rat) |
| 產(chǎn)品應用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 83 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from mouse HSL around the phosphorylation site of Ser660: SK(p-S)HE |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008] Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Subcellular Location: Cell membrane. Membrane, caveola. Cytoplasm,bcytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. Post-translational modifications: Phosphorylation by AMPK may block translocation to lipid droplets. Similarity: Belongs to the 'GDXG' lipolytic enzyme family. SWISS: P54310 Gene ID: 16890 Database links: Entrez Gene: 3991 Human Entrez Gene: 16890 Mouse Omim: 151750 Human SwissProt: Q05469 Human SwissProt: Q6NSL7 Human SwissProt: P54310 Mouse Unigene: 656980 Human Unigene: 158548 Mouse Unigene: 333679 Mouse Unigene: 10566 Rat HSL又稱(chēng)：敏感性甘油三酯脂肪酶，在脂肪動(dòng)員中，脂肪細胞內激素敏感性甘油三酯脂肪酶（HSL）起決定性作用，它是脂肪分解的限速酶，稱(chēng)為激素敏感性脂肪酶。腎上腺素、去甲腎上腺素、胰高血糖素等激活HSL促進(jìn)脂肪動(dòng)員；胰島素，前列腺素E及煙酸等抑制HSL，抑制脂肪的動(dòng)員。 |
