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    Angiotensin II Type 1 Receptor Rabbit pAb (bs-2097R)  
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    50ul/1180.00元
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    產(chǎn)品編號 bs-2097R
    英文名稱(chēng) Angiotensin II Type 1 Receptor Rabbit pAb
    中文名稱(chēng) 血管緊張素Ⅱ-1型受體抗體
    別    名 AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1R; Ang II; Angiotensin II receptor type 1; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT1; AT1R.  
    研究領(lǐng)域 心血管  生長(cháng)因子和激素  新陳代謝  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human,Mouse,Rat (predicted: Rabbit,Cow)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 39 kDa
    檢測分子量
    細胞定位 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human AT1R: 201-300/359 <Cytoplasmic>
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].

    Function:
    Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    Subunit:
    Interacts with MAS1 (Probable). Interacts with ARRB1.

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Liver, lung, adrenal and adrenocortical adenomas.

    Post-translational modifications:
    C-terminal Ser or Thr residues may be phosphorylated.

    DISEASE:
    Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.

    Similarity:
    Belongs to the G-protein coupled receptor 1 family.

    SWISS:
    P30556

    Gene ID:
    185

    Database links:

    Entrez Gene: 185 Human

    Entrez Gene: 11607 Mouse

    Entrez Gene: 11608 Mouse

    Entrez Gene: 24180 Rat

    Entrez Gene: 81638 Rat

    Omim: 106165 Human

    SwissProt: P30556 Human

    SwissProt: P29754 Mouse

    SwissProt: P29755 Mouse

    SwissProt: P25095 Rat

    SwissProt: P29089 Rat

    Unigene: 477887 Human

    Unigene: 728754 Human



    AT1-受體:血管緊張素Ⅱ-1型受體抗體,主要用于心血管病方面的研究。
    產(chǎn)品圖片
    Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin II Type 1 Receptor) Polyclonal Antibody, Unconjugated (bs-2097R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Angiotensin II Type 1 Receptor) Polyclonal Antibody, Unconjugated (bs-2097R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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