| 產(chǎn)品編號 | bs-2510R |
| 英文名稱(chēng) | ZNF217 Rabbit pAb |
| 中文名稱(chēng) | 鋅指蛋白217抗體 |
| 別 名 | zinc finger protein 217; ZABC 1; ZABC1; ZN 217; ZN217; ZNF 217; 4933431C08Rik; AW987152; Gm562; Zfp217; ZN217_HUMAN . |
 |
Specific References (2) | bs-2510R has been referenced in 2 publications.
[IF=5.008] Cohen et al. The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value. (2015) Oncotarget. 6:41566-81 IHC ; Human.
[IF=2.766] Li et al. MiR-203 suppresses ZNF217 upregulation in colorectal cancer and its oncogenicity. (2015) PLoS.One. 10:e0116170 IHC ; Human.
|
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 染色質(zhì)和核信號 信號轉導 轉錄調節因子 結合蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog) |
| 產(chǎn)品應用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 115 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF217: 151-250/1061 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression. Function: Binds to the promoters of target genes and functions as epressor. Promotes cell proliferation and antagonizes cell death. romotes phosphorylation of AKT1 at 'Ser-473'. Subunit: Component of a histone deacetylase complex that contains DAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone eacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, DM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and TF2I. Interacts with CTBP1 and CTBP2. Subcellular Location: Nucleus (Probable). Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers. SWISS: O75362 Gene ID: 7764 Database links: Entrez Gene: 7764 Human Omim: 602967 Human SwissProt: O75362 Human Unigene: 155040 Human Unigene: 711564 Human |
