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    STAT6 Rabbit pAb (bs-1143R)  
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    50ul/1180.00元
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    產(chǎn)品編號 bs-1143R
    英文名稱(chēng) STAT6 Rabbit pAb
    中文名稱(chēng) 信號轉導和轉錄激活因子6抗體
    別    名 signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.  
    Specific References  (2)     |     bs-1143R has been referenced in 2 publications.
    [IF=4.716] Jiang Z et al. Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages. Front Immunol. 2020 Jan 30;11:11.  ICF ;  Mouse.  
    [IF=1.918] Jisheng Wang. et al. Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats. Med Sci Monitor. 2020; 26: e925579-1–e925579-11  WB ;  Rat.  
    研究領(lǐng)域 腫瘤  發(fā)育生物學(xué)  信號轉導  細胞凋亡  轉錄調節因子  表觀(guān)遺傳學(xué)  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human,Mouse,Rat (predicted: Dog)
    產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 94 kDa
    檢測分子量
    細胞定位 細胞核 細胞漿 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human STAT6: 601-700/841 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

    Function:
    Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

    Subunit:
    Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.

    Subcellular Location:
    Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

    Post-translational modifications:
    Tyrosine phosphorylated following stimulation by IL-4 and IL-3.

    Similarity:
    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.

    SWISS:
    P42226

    Gene ID:
    6778

    Database links:

    Entrez Gene: 6778 Human

    Entrez Gene: 20852 Mouse

    Entrez Gene: 362896 Rat

    Omim: 601512 Human

    SwissProt: P42226 Human

    SwissProt: P52633 Mouse

    Unigene: 524518 Human

    Unigene: 121721 Mouse

    Unigene: 6880 Rat



    信息轉導和轉錄激活因子-6(signal transducer and activator of transcription-6,STAT6)是信號轉導和轉錄激活因子(STAT)家族的一員,是一種94kD的蛋白質(zhì)。它通過(guò)JAK-STAT信號轉導途徑介導細胞因子IL-3、IL-4及IL-13誘導的基因表達,特別是在促進(jìn)IL-4誘導的MHCⅡ類(lèi)抗原及免疫球蛋白受體等的表達及Th2細胞和淋巴細胞的發(fā)育上發(fā)揮了重要的作用。
    產(chǎn)品圖片
    Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (STAT6) Polyclonal Antibody, Unconjugated (bs-1143R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (STAT6) Polyclonal Antibody, Unconjugated (bs-1143R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (STAT6) Polyclonal Antibody, Unconjugated (bs-1143R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
    Paraformaldehyde-fixed, paraffin embedded (Human stomach); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxidee for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (STAT6) Polyclonal Antibody, Unconjugated (bs-1143R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
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