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    DFFA Rabbit pAb (bs-0214R)  
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    產(chǎn)品編號 bs-0214R
    英文名稱(chēng) DFFA Rabbit pAb
    中文名稱(chēng) DFFA抗體
    別    名 DNA fragmentation factor subunit alpha; DFF-45; Inhibitor of CAD; ICAD; DFF1; DFF45; H13; DFFA; DFFA_HUMAN;  
    研究領(lǐng)域 細胞生物  免疫學(xué)  染色質(zhì)和核信號  細胞凋亡  新陳代謝  表觀(guān)遺傳學(xué)  
    抗體來(lái)源 Rabbit
    克隆類(lèi)型 Polyclonal
    克 隆 號
    交叉反應 Human,Mouse,Rat
    產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 36 kDa
    檢測分子量
    細胞定位 細胞漿 細胞膜 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human ICAD: 2-100/331 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產(chǎn)品介紹 Caspase-activated deoxyribonuclease(CAD) also designated DNA fragmentation factor 45 kDa subunit (DFF-45)and Caspase-activated DNase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. ICAD (DNA fragmentation factor alpha subunit) (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) is inhibitor of the caspase-activated DNase (DFF44).

    Function:
    Inhibitor of the caspase-activated DNase (DFF40).

    Subunit:
    Heterodimer of DFFA and DFFB.

    Subcellular Location:
    Cytoplasm.

    Post-translational modifications:
    Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.

    Similarity:
    Contains 1 CIDE-N domain.

    SWISS:
    O00273

    Gene ID:
    1676

    Database links:

    Entrez Gene: 1676 Human

    Omim: 601882 Human

    SwissProt: O00273 Human

    Unigene: 484782 Human



    ICAD 是在細胞凋亡期誘導DNA分裂和染色體固縮的一種核酶,降解裸露的DNA 并誘導形態(tài)學(xué)變化。
    產(chǎn)品圖片
    Sample: liver (mouse) Lysate at 40 ug lung(mouse) Lysate at 40 ug BRL-3A (rat)cell Lysate at 40 ug Primary: Anti- ICAD (bs-0214R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36kD Observed band size: 36 kD
    Sample: A431 Cell (Human) Lysate at 40 ug Primary: Anti-ICAD (bs-0214R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 36 kD
    Tissue/cell: Human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ICAD Polyclonal Antibody, Unconjugated(bs-0214R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
    Tissue/cell: human cervical carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ICAD/DFF-45 Beta Polyclonal Antibody, Unconjugated(bs-0214R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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